Wing Werner Kok and long-serving hooker John Andrew are two of 11 senior players who will leave Ulster at the end of the season.
Australia prop Angus Bell will return to the NSW Waratahs after his short-term deal to stay in Belfast comes to an end.
Forwards Matthew Dalton, Marcus Rea, Rory McGuire, Bryan O’Connor and Sean Reffell will leave the Affidea Stadium after the expiry of their contracts.
Experienced scrum-half Dave Shanahan will also leave the province, while Ben Moxham and James Humphreys will also depart.
Academy players Sam Berman, Wilhelm De Klerk, Ethan Graham, Lukas Kenny and Josh Stevens will also leave at the end of the season.
Ulster will look to secure a play-off place against Glasgow Warriors in their final game of the United Rugby Championship regular season on Friday before they take on Montpellier in the Challenge Cup final in Bilbao on 22 May.
“I’d like to thank the players who are moving on for their application and contributions to Ulster Rugby,” said general manager Rory Best.
“I hope that supporters will join us on Friday night after full-time, as we celebrate their efforts and wish them well for the future.”
