Utility back Helena Rowland and Claudia Moloney-MacDonald return from injury to start at fly-half and on the left wing respectively.
Jess Breach, who is one score away from 50 international tries, retains her spot after two tries against the USA, as does impressive outside centre Megan Jones.
Jones is joined by Gloucester-Hartpury’s Jade Shekells in the midfield, with Emma Sing named at full-back.
In the forwards, lock Lilli Ives Campion and flanker Abi Burton are set for World Cup debuts after being named to start.
Maddie Feaunati starts at number eight against the nation her father Zak played for 13 times.
Samoa, who are fully amateur and ranked 15th in the world, lost their opening game 73-0 to Australia.
Given England played two different teams across this year’s Women’s Six Nations and still won a fourth consecutive Grand Slam, they are likely to record a big scoreline in Northampton despite the wholesale changes.
A bonus-point victory will put Mitchell’s side in a strong position to qualify for the knockout stages.
More to follow.
