Musetti was looking for his first win since the Australian Open, where he was forced to retire up two sets on Djokovic in the quarterfinals due to an upper right leg injury. He returned to drop his Indian Wells opener, before withdrawing from the Miami Open with a right arm issue.
In 2025, the Italian followed up his Monte Carlo performance by reaching the semifinals at Madrid, Rome and Roland Garros.
Vacherot takes on Hubert Hurkacz in third-round action Thursday. The Pole previously halted a seven-match losing streak (includes one Challenger appearance) when he eliminated 15th seed Luciano Darderi in the first round, before adding a 6-2, 6-3 victory over Fabian Marozsan today.
Musetti’s compatriot Flavio Cobolli also exited in his opener. Belgian qualifier Alexander Blockx upset the No. 10 seed, 6-3, 6-3, saving all five break points he faced. Former champion Andrey Rublev was also sent packing, as Zizou Bergs ousted the No. 13 seed with his 6-4, 6- 1 dismissal.
