Change this weekend has not been limited merely to the coaching box.
Sherratt has made eight personnel switches from the side that lost against Italy last time out, along with two positional alterations.
Scarlets wing Ellis Mee, off the back of just 10 senior outings for his region, will make his Wales debut, while significantly there are returns for Gareth Anscombe and WillGriff John.
The former has not played in this competition since Wales clinched the Grand Slam six years ago, also against Ireland. The latter makes his Six Nations debut having not played international rugby for three and a half years.
For Wales, perhaps it was to be expected that a new broom would sweep clean.
But despite the winning formula utilised in the first two games, Easterby has made seven changes to his side too, with just two of them forced by injuries.
With the likes of James Ryan, Bundee Aki and Finlay Bealham held in reserve, and Hugo Keenan not involved at all, this is by some way the most callow line-up Ireland have named so far in this championship.
Replacement loose-head Jack Boyle will make his Ireland debut should he be used from the bench, while tight-head Tom Clarkson is set for his first start.
Jamie Osborne, Gus McCarthy, Cian Prendergast have never before featured in the Six Nations.
Injury, meanwhile, means Ireland go into a Test match without their influential captain Caelan Doris for the first time in four years.
As the number eight’s incredible streak comes to an end, his positional replacement Jack Conan said the side’s back row will be “under a huge amount of pressure” to compensate for his absence.
Hooker Dan Sheehan, meanwhile, will captain the side for the first time and believes the onus of leadership can be shared among the squad.
“We wish that Caelan wasn’t injured but someone had to step up,” said the 26-year-old.
“I was asked on Monday and I was absolutely delighted to take that responsibility. It’s something I’ve enjoyed so far.
“This team sort of runs itself with the leaders that are in it. There are a handful of people who could have been named captain – Pete [O’Mahony], Tadhg Beirne, Jamo [Gibson-Park], Jack Conan.
“A lot of them have huge amounts of leadership and they help to run the week as well. Obviously my name gets the ‘c’ beside it but we know in our group we rely on a lot of people.”
