Munster’s Peter O’Mahony has been ruled out while Saracens have recalled Liam Williams and Phil Brantingham for Saturday’s Investec Champions Cup pool match at Thomond Park (17:30 GMT).
Jack Crowley, Conor Murray and Jack O’Donoghue all return for the hosts, but former club captain O’Mahony misses out having failed to recover from the calf contusion that has kept him out for a month.
For Saracens, who beat Bristol in the Premiership last week, Brantingham starts at loosehead prop in place of Rhys Carre, who has a back injury.
Wales international Williams, who scored in Saracens’ win over Stade Francais in December, replaces Rotimi Segun on the right wing.
Saracens captain Maro Itoje will make his 50th Champions Cup appearance with Harry Wilson set for his full debut in the competition.
England hooker Theo Dan is named among the replacements having recovered from a calf issue while Max Eke and Nathan Michelow could make their Champions Cup debuts from the bench.
Saracens have won both of their pool games so far while Munster lost to Castres last time out having beaten Stade Francais in their opener. The Irish province lost to Leinster in their last game on 27 December.
Munster: M Haley; C Nash, T Farrell, R Scannell, S Daly; J Crowley, C Murray; D Bleuler, N Scannell, O Jager; F Wycherley, T Beirne (capt); J O’Donoghue, A Kendellen, G Coombes.
Replacements: D Barron, J Ryan, S Archer, T Ahern, J Hodnett, P Patterson, B Burns, B Gleeson.
Saracens: E Daly; L Williams, A Lozowski, N Tompkins, L Cinti; F Burke, I van Zyl; P Brantingham, J George, M Riccioni; M Itoje (capt), H Wilson; JM Gonzalez, B Earl, T Willis.
Replacements: T Dan, E Mawi, A Clarey, M Eke, N Michelow, G Simpson, O Hartley, T Elliott.
