Mack Hansen returns for Connacht for the trip to Thomand Park, playing his first game since a serious shoulder injury sustained on New Year’s Day.
Santiago Cordero starts after playing for Argentina in the Rugby Championship and Josh Murphy will play his first game since May 2023.
New arrivals Ben Murphy, Josh Ioane and Piers O’Conor are included as Cian Prendergast captains the side for the first time.
Connacht: Santiago Cordero, Mack Hansen, Piers O’Conor, Cathal Forde, Shayne Bolton, Josh Ioane, Ben Murphy, Denis Buckley, Dave Heffernan, Jack Aungie, Joe Joyce, Darragh Murray, Josh Murphy, Conor Oliver, Cian Prendergast (C).
Replacements: Dylan Tierney-Martin, Peter Dooley, Sam Illo, Oisin Dowling, Shamus Hurley-Langton, Caolin Blade, David Hawkshaw, Sean Jansen.