Keys had a 6-3, 6-3 win over Beatrice Haddad Maia of Brazil. Haddad Maia won the Korea Open last week but struggled to combat the baseline power of Keys.
Former No. 1 Naomi Osaka continued her positive start with new coach Patrick Mouratoglou with a 6-3, 6-2 victory over Katie Volynets, advancing to a round-of-16 match against sixth-ranked Coco Gauff.
It will be the first meeting between the two Grand Slam champions in more than two years, with the head-to-head series tied at 2-2.
“It’s going to be a really cool test for me,” Osaka said. “She’s played really well this year. I’m excited to play the match, and I know people are excited to watch the match.”
Osaka, who returned from maternity leave at the start of this season and is No. 73 in the current rankings, fired five aces and produced three service breaks.
The four-time major winner joined Mouratoglou shortly before the China Open after splitting with Wim Fisette. Her run here so far is the first time since May that Osaka has had three consecutive wins.
Fifth-ranked Jasmine Paolini had a day to forget as she was humbled 6-4, 6-0 by No. 45-ranked Magda Linette of Poland.