George Ford will become the seventh man to make 100 Test appearances for England when he starts at fly-half in the first Test against Argentina on Saturday.
Ford, 32, made his England debut against Wales in the 2014 Six Nations and was a key part of the side that reached the Rugby World Cup final in 2019.
Elsewhere, centre Seb Atkinson and wing Will Muir both win their first England caps, with uncapped Bath back row Guy Pepper on the bench.
Ford shares the captaincy with hooker Jamie George, with Northampton’s Alex Coles partnering Charlie Ewels in the second row and flanker Sam Underhill making his Test comeback after missing the Six Nations with an ankle injury.
England: Steward; Roebuck, Slade, S Atkinson, Muir; Ford, Spencer; Baxter, George, Heyes, Ewels, Coles, B Curry, Underhill, Willis.
Replacements: Dan, Rodd, Opoku-Fordjour, Cunningham-South, Pepper, Dombrandt, van Poortvliet
