Elliot Daly will play for the first time since breaking his arm on British & Irish Lions duty in June as he starts on the wing for England against Argentina on Sunday.
The 33-year-old replaces Tom Roebuck, who suffered a foot injury in last weekend’s 33-19 win over New Zealand.
Daly’s inclusion is one of six changes to the starting XV as coach Steve Borthwick, whose hand is partly forced by injury, experiments with more combinations.
Henry Slade makes his first England start since February with outside centre Ollie Lawrence ruled out with a hamstring problem.
Elsewhere, there is an all-new front row with Ellis Genge and Luke Cowan-Dickie recalled alongside Asher Opoku-Fordjour, who makes only his second Test start.
Ben Spencer starts at scrum-half, while Theo Dan is named on the bench with Saracens team-mate Jamie George ruled out with hamstring trouble.
Marcus Smith is on the bench once more, with full-back Freddie Steward showing no signs of concussion after a head knock against the All Blacks, and fly-half George Ford, who scored 13 points last weekend, retained.
England are chasing an 11th successive victory to round off a hugely encouraging 2025 in style.
Argentina are aiming to complete a hat-trick of wins on their northern hemisphere tour, having thrashed Wales 52-28 and fought back to overcome Scotland 33-24 last weekend.
They will have to buck historical trends to do so, having won only five of the 29 previous Test meetings. However, the Pumas were victorious on their last visit to Twickenham, edging a 2022 contest by a single point.
England: Steward; Feyi-Waboso, Slade, Dingwall, Daly; Ford, Spencer; Genge, Cowan-Dickie, Opoku-Fordjour, Itoje, Coles, Pepper, Underhill, Earl.
Replacements: Dan, Baxter, Stuart, Ewels, T Curry, Pollock, Mitchell, M Smith.
